Our study cohort included a wide range of ages, both the juveniles and adults. predicting SLE. The statistical analysis was carried out using SPSS 17.0 (Chicago, IL). ideals .05 were considered statistically significant. 3.?Results 3.1. Baseline characteristics of sample human population Patient group experienced a median age of 25 years (range 16C45), having a sex distribution of 93 ladies (88.6%) and 12 men (11.4%). The median age was 27 years in the control group (range 16C46), having a sex distribution of 92 ladies (87.6%) and 13 men (12.4%). No statistically Rabbit Polyclonal to GPR174 significant variations were observed in age and sex between patient and control organizations ( em P /em ?=?.837 and em P /em ?=?.831, respectively) (Table ?(Table11). Table 1 Fundamental characteristics and laboratory results of individuals and control group. Open in a separate windowpane 3.2. PLR and RPR were improved in SLE individuals while MPV was decreased The levels of RPR and PLR were improved in SLE individuals, whereas MPV was decreased as compared with healthy controls. There was a statistically significant difference in RPR, PLR, and MPV between the patient and control organizations Begacestat (GSI-953) (both em P /em ? ?.001). We found that SLE individuals experienced lower neutrophil count, lymphocyte count, and hemoglobin than the healthy controls. WBC and platelet counts were decreased, but were within Begacestat (GSI-953) normal limits (Table ?(Table1,1, Fig. ?Fig.11). Open in a separate window Begacestat (GSI-953) Number 1 Assessment of PLR, RPR, and MPV in SLE individuals and healthy settings. (A) PLR level was significantly improved in SLE individuals. (B) RPR level was significantly improved in SLE individuals. (C) MPV was decreased in SLE individuals (all em P /em ? ?.05). MPV?=?mean platelet volume, PLR?=?platelet-to-lymphocyte percentage, RPR?=?red blood cell distribution width-to-platelet ratio, SLE?=?systemic lupus erythematosus. 3.3. RPR was associated with SLE medical disease activity With this study, individuals in group 1 (SLEDAI score 9) experienced an RPR of 0.078 (range 0.059C0.088), whereas individuals in group 2 (SLEDAI 9) had a higher RPR of 0.081 (0.066C0.119). The variations in RPR between the 2 organizations were statistically significant ( em P /em ?=?.015). Additional medical indicators relating to SLEDAI score subgroups were shown in Table ?Table2.2. Individuals with higher SLEDAI score experienced higher anti-dsDNA antibody, urine protein, serum IgG and ESR, whereas match C3, C4, and albumin were decreased significantly. Table 2 Laboratory data of individuals relating to SLEDAI scores. Open in a separate windowpane 3.4. Effect of glucocorticoid treatment on PLR, RPR, and MPV Glucocorticoids are widely used to treat individuals with autoimmune diseases such as SLE, [22] as it is an effective anti-inflammatory and immunosuppressive agent. To investigate the effects of glucocorticoid treatment, we analyzed changes in the laboratory guidelines of SLE individuals before and after treatment. As demonstrated in Fig. ?Fig.2,2, we found that PLR and RPR were decreased after treatment, accompanied by a decrease of both anti-dsDNA and SLEDAI. All variations were statistically significant, except the effect of treatment on MPV. Open in a separate window Number 2 Assessment of PLR, RPR, and anti-dsDNA before and after treatment. All 3 signals of SLE were reduced after treatment ( em P /em ? ?.05). dsDNA?=?antidouble-stranded antibody, PLR?=?platelet-to-lymphocyte percentage, RPR?=?red blood cell distribution width-to-platelet ratio, SLE?=?systemic lupus erythematosus. 3.5. Correlations of RPR with medical guidelines of SLE individuals The SLEDAI scores were positively correlated with RPR, MPV, ESR, urine protein, and anti-dsDNA, whereas this score displayed a negative relationship with WBC, hemoglobin, PLT, albumin, and match C3 and C4 ( em P /em ? ?.05 for those). RPR was positively correlated with SLEDAI ( em r /em ?=?0.368, em P /em ? ?.001), ESR ( em r /em ?=?0.313, em P /em ?=?.027), anti-dsDNA ( em r /em ?=?0.275, em P /em ?=?.036), and urine protein ( em r Begacestat (GSI-953) /em ?=?0.25, Begacestat (GSI-953) em P /em ?=?.01), whereas it was negatively correlated with match C3 and C4, and albumin ( em P /em ? ?.05 for those). Interestingly, RPR, PLR, and MPV were each found to be correlated with the additional 2 actions ( em P /em ? ?.001) (Table ?(Table3,3, Fig. ?Fig.33). Table 3 Correlation of SLEDAI score and RPR with laboratory indices in SLE. Open in a separate windowpane Open in a separate windowpane Number 3 Correlation between SLEDAI and RPR, MPV, anti-dsDNA, and PLT in SLE individuals. Spearman correlation analysis was performed to examine the association between SLEDAI and RPR, and other laboratory guidelines. (A) RPR level was positively correlated with SLEDAI score. (B) MPV was positively correlated with SLEDAI score. (C) Anti-dsDNA was positively correlated with SLEDAI score. (D) PLT was negatively correlated with SLEDAI score (all.